HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by van Hoosier, G. L. Articles by Trentin, J. J. Search for Related Content PubMed Articles by van Hoosier, G. L., Jr. Articles by Trentin, J. J.

Evidence for the IgG Nature of Complement-Fixing (CF) Antibodies to Adenovirus Type 12 Hamster Tumor Neoantigens¹

Division of Experimental Biology, Baylor University College of Medicine, Texas Medical Center, Houston, Texas

Abstract

Sera from hamsters bearing transplants of adenovirus type 12 (A-12) tumors, and containing CF antibodies reactive with antigens prepared from such tumors, were characterized to determine the immunoglobulin class of these antibodies. Differential characteristics studied were zonal sedimentation in a sucrose density gradient, susceptibility to reduction by mercaptoethanol, persistence following tumor ablation, and placental transfer. The findings indicate that the CF antibodies to A-12 hamster tumors are of the IgG or 7 S type.

Footnotes

This investigation was supported by Public Health Service Grants CA 06941, CA 05021 and K6 CA 14,219.

Presented in part at the annual meeting of the American Association of Immunologists, Chicago, Illinois, 1967 (Fed. Proc., 26: 481, 1967).