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The Pathogenicity in Mice of Aerosols of Encephalomyocarditis Group Viruses or Their Infectious Nucleic Acids¹

Naval Biological Laboratory, School of Public Health, University of California, Berkeley, California

Abstract

When mice were exposed to aerosols of different strains of the encephalomyocarditis virus group or Mengo RNA, the observed differences in pathogenicity were correlated with plaque size, state of the virus (intact or RNA) and the presence or absence of circulating antibodies. With aerosols of Mengo-37A, a small plaque-forming immunogenic strain, virus was recovered from the lungs, intestines, spleen, liver and blood. Pathologic changes occurred in the lungs and heart. Mice exposed to lethal aerosols of Mengo or Col-SK (large plaque-forming strains) yielded virus from every organ. However, with lethal Mengo RNA aerosols there was a delayed appearance of virus in the intestinal tract. Mice exposed to lethal Mengo RNA, Col-SK and Mengo virus aerosols exhibited similar pathologic changes, which occurred only in brain and liver tissues. Challenge with lethal Col-SK or Mengo aerosols resulted in no deaths of Mengo-37A immunized mice. However, challenge virus was recovered from the lungs, intestinal tract, spleen, liver and blood. Pathologic changes were also observed in lung and liver tissues. RNA aerosol exposure of mice immunized with Mengo-37A resulted in virus being isolated from lung tissue only.

Footnotes

¹ This work was sponsored by the Office of Naval Research under a contract with the Regents of the University of California. Reproduction in whole or in part is permitted for any purpose of the United States Government.

² Naval Medical Research Unit 1, University of California, Berkeley.