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The Action of Pancreatic Extracts on Complement

From the School of Medicine, Leeds, and Department of Bacteriology, Durham University

Abstract

1. Pancreatic extracts acting upon whole guinea-pig's serum first destroy the end-piece or albumin fraction. If the reaction is allowed to proceed for a much longer period, both components of the complement are hydrolyzed. In this way the destruction of the complement action of whole serum runs parallel to the destruction by heating at 56°C.

2. The isolated mid-piece and end-piece fractions are both fairly rapidly destroyed by the enzyme extracts, the latter being more resistant to the enzyme action than the mid-piece fractions. This greater resistance of the end-piece fraction is attributed to the presence in it of the anti-trypsin present in the serum.