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Studies in Specific Hypersensitiveness

XV. On the Nature of the Atopens of Pollens, House Dust, Horse Dander and Green Pea

From the Department of Bacteriology and Immunology, Division of Immunology, in Cornell University Medical College and the New York Hospital

Abstract

The removal of all protein and other detectable nitrogenous substances from pollen and house dust extracts, by means of tryptic digestion and dialysis, causes no appreciable lessening of the atopic activity of the extracts.

These atopens seem, therefore, not to be proteins, in the usual sense.

The tryptic digestion of the proteins of horse dander and of green pea causes a diminution of atopic activity, corresponding with the loss of protein by the digestion.

The atopens of horse dander and of green pea appear, thus, to be of protein nature.

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