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Studies in Hypersensitiveness

XIV. A Study of the House Dust Atopen in Asthma

From the Department of Bacteriology and Immunology, Division of Immunology, in Cornell University Medical College and the New York Hospital

Abstract

The foregoing is an experimental study of a case of atopic hypersensitiveness (asthma) in which house dust was shown to be an exciting cause, a constitutional reaction having been produced on 2 occasions by the injection of the same small quantity, 0.1 cc., of the dust extract.

R. A. Cooke's opinion that house dust contains a specific excitant of atopy is confirmed by the demonstration, in the blood of a dust sensitive individual, of a specific reagin with which a normal skin site could be sensitized to the dust atopen.

With the use of the method of local passive transfer (Prausnitz and Kustner) it could be shown that the dust atopen was not a product of horse dander, to which latter material the individual was also slightly sensitive.

With the same technical method results were obtained which seemed to indicate the existence of more than one dust atopen.

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