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A Study of the Complement Fixation Reaction in Tuberculosis

From the Division of Laboratories and Research, New York State Department of Health, Albany

Abstract

This study was started in 1917 for the purpose of ascertaining the practical value of the complement fixation reaction in the diagnosis of tuberculosis. From the outset, it was realized that a systematic and thorough investigation would involve experimental research into the mechanism of the immune reaction which might bring out new facts of fundamental significance. Two important observations have already been published: the adsorption by globulin and the extraction from the precipitated globulin of substances in bacterial cultures which possess antigenic activity (1); and the relationship of fibrinogen to certain agglutinative and lytic properties of the blood (2).

It is the purpose of this paper to record the results of further study. First, analyses of cultures of the tubercle bacillus by methods of extraction, to determine the distribution of the antigenic properties, were undertaken.