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Interviews with Pillars Commentators
Authors of the Pillars of Immunology commentaries share personal insights into how the featured article(s) impacted their work.
- Dec 1 2018 issue
Dr. Mark Kaplan discusses a 1989 Science paper by Gerald Crabtree that demonstrated the mechanism by which cyclosporin A inhibited T cell activation.
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- Nov 1 2018 issue
Dr. Uttiya Basu discusses a 1999 paper by the group of Tasuku Honjo that demonstrates a critical role for activation-induced cytidine deaminase in class switch recombination and somatic hypermutation of B cells.
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- Oct 1 2018 issue
Dr. Luc van Kaer discusses a 1994 paper by the group of Dr. Don Wiley that demonstrated the binding of superantigens with the MHC class II molecule.
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- Sep 1 2018 issue
Dr. Martin F. Flajnik discusses a 2004 Nature paper by Drs. Max Cooper and Zeev Pancer that identified the existence of variable lymphocyte receptors which were generated by non-RAG-based rearrangement events.
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- Aug 1 2018 issue
Dr. Wolf H. Fridman discusses a 2001 paper by the group of Robert Schreiber that established the foundations of modern immuno-oncology.
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- Jul 1 2018 issue
Dr. Philippa Marrack discusses a 1994 Nature paper by Charles Surh and Jonathan Sprent that identified apoptotic cells in the thymus during positive and negative selection.
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- Jun 1 2018 issue
Dr. Jordan Orange discusses a 1994 Cell paper by Ute Francke that reported the discovery of the Wiskott–Aldrich syndrome protein gene.
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- May 1 2018 issue
Dr. Wendy Havran discusses a 2001 paper by Adrian Hayday that demonstrates anti-tumor functions for skin-resident gamma delta T cells.
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- Apr 1 2018 issue
Dr. Eric Vivier discusses a 1999 paper by Thomas Spies that revealed a new mode of immune recognition via NKG2D on NK cells.
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- Mar 1 2018 issue
Dr. Marc Peters-Golden discusses a 1978 paper by Robert Murphy and Bengt Samuelsson that provided the first structural characterization of leukotriene C4.
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- Feb 1 2018 issue
Dr. Sebastian Amigorena discusses a 1994 paper by Sallusto and Lanzavecchia that made significant contributions to the field of dendritic cell biology.
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- Jan 1 2018 issue
Dr. Patricia Gearhart discusses a 1965 paper from Michael Potter and the Michael Potter Homogenous Immunoglobulin workshops held at the NIH.
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- Dec 1 2017 issue
Dr. James Hagman discusses a 1997 paper from the laboratory of Tak Mak, which first described the phenotype of T and B cells in mice lacking IRF4.
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- Nov 1 2017 issue
Dr. Jane Buckner discusses 1974 papers from Bottazzo and MacCuish that were instrumental in determining that autoantibodies are directed at pancreatic islet cells in type I diabetes.
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- Oct 1 2017 issue
Dr. Klaus Ley discusses Charles Mills’ 2000 article, published in The JI, describing the M1/M2 polarization axis of macrophages.
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- Sep 1 2017 issue
Dr. Pamela Schwartzberg discusses Cox Terhorst’s 1998 paper published in Nature that identified the gene encoding the SLAM protein SAP, which was later found to be mutated in X-linked proliferative syndrome.
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- Aug 1 2017 issue
Dr. Andrea Cooper discusses Ian Orme’s seminal work, published in 1987 in The JI, describing the kinetics, phenotype, and function of T cells responding to Mycobacterium tuberculosis.
J. Immunol. 138: 293–298 (1987)
[ Text ] [ Audio ] - July 1 2017 issue
Dr. Ranjan Sen discusses a 2000 article from the Krangel group that identified a chromatin-based mechanism for the regulation of V(D)J recombination.
[ Text ] [ Audio ] - June 1 2017 issue
Dr. Gabrielle Belz discusses a 1998 article from the Steinman group that revealed that monocytes could respond to a variety of cues, including non-cytokine cues, to differentiate into dendritic cells.
[ Text ] [ Audio ] - May 1 2017 issue
Dr. Reinhard Hohlfeld discusses a 1981 article describing the isolation and transfer of antigen-specific T lymphocytes capable of mediating autoimmune encephalomyelitis.
[ Text ] [ Audio ] - April 1 2017 issue
Dr. Glenn Dranoff talks about a 1984 article on the cloning of Granulocyte-Macrophage Colony Stimulating Factor.
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- March 1 2017 issue
Dr. Jiri Mestecky discusses a 1974 article in The JI on Per Brandtzaeg's model for transport of secretory IgA.
J. Immunol. 112:
[ Text ][ Audio ] - February 1 2017 issue
Dr. Jeffrey Bluestone discusses three articles published in 2003 that describe the discovery of FOXP3 as the determinant of Treg cell fate and function.
[ Text ][ Audio ] - January 1 2017 issue
Dr. Finkelman discusses two 1966 articles from The Journal of Immunology on the identification of IgE as the allergy-associated immunoglobulin isotype.
J. Immunol. 97: 75-85 (1966) | J. Immunol. 97: 840-853 (1966)
[ Text ][ Audio ] - December 1 2016 issue
Dr. Michael Cancro speaks about a 1992 article describing the molecule (now termed CD154) that transduces the signal for Th-dependent B cell activation.
[ Text ][ Audio ] - November 1 2016 issue
Dr. Kristen Hogquist discusses two of the most highly cited papers in the 100-year history of The Journal of Immunology, papers which describe the function or characterization of monoclonal antibodies to the human and mouse T cell receptors.
J. Immunol. 124: 2708-2713 (1980) | J. Immunol. 142: 2736-2742 (1989)
[ Text ][ Audio ] - October 1 2016 issue
Dr. Gabriel Núñez speaks about a 1999 article by Shizuo Akira’s group which showed by both functional and genetic studies that TLR4 is the receptor for LPS.
J. Immunol. 162: 3749-3752 (1999)
[ Text ][ Audio ] - September 1 2016 issue
Dr. Jay Kolls discusses three foundational articles published in The Journal of Immunology about the function of IL-10, two by Fiorentino and colleagues in 1991 and one by Steinbrink et al. in 1997.
J. Immunol. 146: 3444-3451 (1991) | J. Immunol. 147: 3815-3822 (1991) | J. Immunol. 159: 4772-4780 (1997)
[ Text ][ Audio ] - August 1 2016 issue
Dr. Robert Fairchild discusses a 1983 article by Bass and coworkers on the use of flow cytometry in the intracellular analysis of NADPH oxidase function in human neutrophils.
J. Immunol. 130: 1910-1917 (1983)
[ Text ][ Audio ] - July 1 2016 issue
Dr. Frank Fitch discusses a 1978 article describing an assay for T cell growth factor (later renamed IL-2) and its application in the study of lymphocytes.
J. Immunol. 120: 2027–2032 (1978)
[ Text ][ Audio ] - June 1 2016 issue
Dr. Anne O'Garra talks about the 1997 work of Zheng and Flavell on the role of GATA-3 in Th2 cytokine gene expression in CD4 T cells.
[ Text ][ Audio ] - May 1 2016 issue
Dr. Willi Born discusses two 1986 articles by Brenner and Bank and their colleagues, on the discovery of the gamma- delta T-cell receptor.
[ Text ][ Audio ] - April 1 2016 issue
Dr. Diane Mathis speaks about work from Bruno Kyewski's group on the role of thymic expression of peripheral tissue antigens in the induction of central tolerance.
[ Text ][ Audio ] - March 1 2016 issue
Dr. Littman discusses work by Al Singer's group on the "kinetic signaling" model of T cell lineage choice.
[ Text ][ Audio ] - February 1 2016 issue
Dr. Unanue talks about about the work of Rudensky and colleagues on the sequence analysis of peptides bound to MHC class II molecules.
[ Text ][ Audio ] - January 1 2016 issue
Dr. Gwen Randolph speaks about the seminal work of Reinhold Förster and colleagues on the role of CCR7 in the primary immune response.
[ Text ][ Audio ] - December 1 2015 issue
Dr. Michael Krangel discusses an article from Mark Schlissel and colleagues that showed for the first time that chromatin structure determines the targeting of V(D)J recombinase activity.
[ Text ][ Audio ] - November 1 2015 issue
Dr. Chandra Mohan discusses the 1994 article by Ward Wakeland and colleagues that described the chromosomal locations of genetic loci linked to murine lupus.
[ Text ][ Audio ] - October 1 2015 issue
Dr. David Raulet talks about two 1971 articles by Cudkowicz and Bennett which examined rejection of allogeneic cells and the phenomenon of hybrid resistance.
[ Text ][ Audio ] - September 1 2015 issue
Dr. Michael Gale speaks about the discovery in 1957 of type I interferon by Alick Isaacs and Jean Lindenmann.
[ Text ][ Audio ] - August 1 2015 issue
Dr. Suzanne Cory discusses the 1999 publication that described how commitment to the B- lymphoid lineage depends on the transcription factor Pax5.
[ Text ][ Audio ] - July 1 2015 issue
Dr. David Fox discusses a 1998 article by Schellekens et al. which showed that the amino acid citrulline was an essential component of the determinant recognized by anti-fillagrin autoantibodies in rheumatoid arthritis.
[ Text ][ Audio ] - June 1 2015 issue
Dr. Randy Cron speaks about the identification of perforin as the first gene determined to be defective in patients with familial hemophagocytic lymphohistiocytosis.
[ Text ][ Audio ] - May 1 2015 issue
Dr. Janis Burkhardt discusses two articles that advanced the understanding of the immunological synapse.
[ Text ][ Audio ] - April 1 2015 issue
Dr. Steven Reiner talks about the publication that identified the transcription factor T-bet, a key factor in Type-I immunity.
[ Text ][ Audio ] - March 1 2015 issue
Dr. Klaus Rajewsky discusses the publication in 2002 of a DNA deamination model of somatic antibody diversification.
[ Text ][ Audio ] - February 1 2015 issue
Dr. Graham Anderson talks about the identification in 1994 of the gene responsible for defective thymus development in nude mice.
[ Text ][ Audio ] - January 1 2015 issue
Dr. Pamela Bjorkman speaks about how the 1993 publication of the first crystal structure of a class II MHC protein impacted the field.
[ Text ][ Audio ] - December 1 2014 issue
Dr. Bill Nauseef discusses a 1973 article that looked at the role of superoxide anion as the product of phagocyte oxidase.
[ Text ][ Audio ] - November 1 2014 issue
Dr. Larry Kane discusses a 1994 article that established that T cell receptor signal transduction is initiated by the sequential interaction of two tyrosine kinases with the TCR.
[ Text ][ Audio ] - October 1 2014 issue
Dr. Alan Aderem discusses two articles by George Mackaness who demonstrated that macrophages can serve as effector cells for acquired cell-mediated immunity.
[ Text ][ Audio ] - September 1 2014 issue
Dr. Lewis Lanier discusses the work of the late Leonard Herzenberg and the early days of FACS.
[ Text ][ Audio ] - August 1 2014 issue
Dr. Mitchell Kronenberg speaks about two articles that led to the discovery of expanded T lymphocyte populations with a limited TCR α chain diversity.
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In This Issue
A small number of papers regarded by reviewers and editors as the top 10% in their field are highlighted in this section.
- July 15 2014 issue
Summaries of articles highlighting "Editing Ets1 Expression" and how "Fibroblasts Modulate Macrophages."
[ Text ] [ Audio ] - July 1 2014 issue
Summaries of articles highlighting "age-specific CD8+T cell differences between adults and neonates in response to infection" and how "variations in cattle WC1 expression alter signal transduction during γδ T cell responses to bacteria."
[ Text ] [ Audio ] - June 15 2014 issue
Summaries of articles highlighting "a Fas-mediated apoptotic mechanism that alleviates tumor-associated immune suppression" and how "unregulated TLR signaling in DCs can promote autoimmunity."
[ Text ] [ Audio ] - June 1 2014 issue
Summaries of articles highlighting "MIF as a B cell chemokine" and "the role of basophil extracellular traps in innate immune defense."
[ Text ] [ Audio ] - May 15 2014 issue
Summaries of articles highlighting "a potential role for MDSCs in TB progression" and "a regulatory IL-17-dependent mechanism in helminthic disease."
[ Text ] [ Audio ] - May 1 2014 issue
Summaries of articles highlighting "the important role of uric acid in the initiation of allergic responses" and "a mechanism by which TReg directly induce B cell anergy and help prevent the development of autoimmunity."
[ Text ] [ Audio ] - April 15 2014 issue
Summaries of articles highlighting "a regulatory pathway by which an ER-localized protein promotes the pathogenesis of asthma" and "the extensive genetic diversity in B cells responding to HIV-1 envelope glycoprotein vaccination."
[ Text ] [ Audio ] - April 1 2014 issue
Summaries of articles highlighting "mechanisms by which FcγRIIB expression on different cell types, and at different stages of differentiation, may control peripheral tolerance" and how "G-CSF stem cell mobilization attenuates GVHD by promoting Treg expansion and function."
[ Text ] [ Audio ] - March 15 2014 issue
Summaries of articles highlighting how "TMP778, a human RORγt inverse agonist, inhibits Il-17 in psoriasis" and how "coinhibitory signals can downregulate T cell activation in EAE."
[ Text ] [ Audio ] - March 1 2014 issue
Summaries of articles highlighting "a prominent role for IgA in mucosal inflammatory responses" and how "MAC inhibition can improve neurological recovery after traumatic brain injury."
[ Text ] [ Audio ] - February 15 2014 issue
Summaries of articles highlighting "a molecular mechanism by which DUSP14 dampens T cell activation" and how "a transcription factor, Nfil3, functions in maintaining homeostasis between immune cells and the microbiota in the intestine."
[ Text ] [ Audio ] - February 1 2014 issue
Summaries of articles highlighting "a key role for B cell-specific Lyn signaling in protection from autoimmunity" and how "adoptive transfer of immune T cells can overcome local and systemic immunosuppression driven by myeloid cells."
[ Text ] [ Audio ] - January 15 2014 issue
Summaries of articles highlighting how "pDCs acquire tumor cell membrane components and efficiently present tumor cell-derived Ags" and how "insulin modulates the suppressive function of Tregs."
[ Text ] [ Audio ] - January 1 2014 issue
Summaries of articles highlighting "a role for TGF-β in blocking immune suppression by mesenchymal stem cells" and how "TRAF5 fucntions as an important negative regulator of TLR-mediated B cell stimulation."
[ Text ] [ Audio ] - December 15 2013 issue
Summaries of articles highlighting "the anti-microbial properties of the urocortin II neuropeptide" and "a mechanism by which the chaperone Grp170 helps facilitate cross-presentation and enhance tumor vaccine efficacy."
[ Text ] [ Audio ] - December 1 2013 issue
Summaries of articles highlighting "the different kinetics of the contraction phase between CD8+ and CD4+ T cells following acute viral infection" and "a mechanism by which iNKT-derived IL-4 prevents GVHD in allogeneic transplantation."
[ Text ] [ Audio ] - November 15 2013 issue
Summaries of articles highlighting "a small molecule inhibitor of HLA-DR2b as a promising therapeutic strategy for the treatment of MS" and "a mechanism by which IL-1 and LPS work together to activate platelets."
[ Text ] [ Audio ] - November 1 2013 issue
Summaries of articles highlighting "a new therapeutic target for Hemolytic uremic syndrome" and how "TNF-α can modulate circadian timing in astrocytes."
[ Text ] [ Audio ] - October 15 2013 issue
Summaries of articles highlighting "a mechanism by which HIV-1 directly activates the innate immune response in the female reproductive tract during sexual transmission" and "a unique role for C1q as a "molecular bridge" between host cells and pneumococci that functions to increase bacterial adhesion and invasion."
[ Text ] [ Audio ] - October 1 2013 issue
Summaries of articles highlighting how "IFN-α secreted during viral reactivation may lead to the accumulation of highly differentiated, but senescent, CD8+ T cells" and how "H. pylori decreases B7-H2 expression through CagA, dampening Th17 responses, thus facilitating bacterial persistence."
[ Text ] [ Audio ] - September 15 2013 issue
Summaries of articles highlighting how "tailoring TCR gene therapy increases the efficacy of tumoricidal T cells in immunosuppressive tumor environments" and how "DNA methylation modulates the formation and maintenance of CD8+ effector T cells during immune responses."
[ Text ] [ Audio ] - September 1 2013 issue
Summaries of articles describing the real-time visualization of cytotoxic lymphocyte killing and steps toward a universal influenza vaccine.
[ Text ] [ Audio ] - August 15 2013 issue
Summaries of articles describing how peptide editors control the pMHCI repertoire and the regulation of beneficial intratumoral high endothelial venules in breast cancer.
[ Text ] [ Audio ] - August 1 2013 issue
Summaries of articles describing a way to increase zoledronate activity to enhance γδ T cell-mediated antitumor immunity and a mechanism driving helper T cell phenotypic changes during autoimmune disease.
[ Text ] [ Audio ] - July 15 2013 issue
Summaries of articles describing an effective way to treat porcine sepsis and identifying potential targets for antimalarial vaccines.
[ Text ] [ Audio ] - July 1 2013 issue
Summaries of articles identifying how proteasome subunits affect the antiviral T cell repertoire and how skin-specific autoimmunity can result in fatal lung disease.
[ Text ] [ Audio ] - June 15 2013 issue
Summaries of articles identifying "a role for miR-155 in the regulation of Th17 cells in EAE" and how "the uracil-DNA glycosylase enzyme is necessary for correct class switch recombination during acute but not chronic immune responses."
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- June 1 2013 issue
Summaries of articles highlighting how a "smaller, less complex version of human Factor H (FH), MINI-FH, can inhibit the alternative pathway of complement activation" and how "pyroptosis may be involved in severe Ulcerative colitis through the combined actions of TLR2 and MDR1."
[ Text ] [ Audio ] - May 15 2013 issue
Summaries of articles highlighting "the importance of IFNAR1 signaling in CD8+ T cell-mediated protection against ECM" and how "IL-22 regulates the composition of the colonic microbiota leading to a transmissible susceptibility to inflammatory colitis."
[ Text ] [ Audio ] - May 1 2013 issue
Summaries of articles highlighting how "anti-PD-L1 and anti-LAG-3 Abs in combination can mediate recurrent tumor regression" and how "Id2 modulates peripheral CD8+ T cell fate."
[ Text ] [ Audio ] - April 15 2013 issue
Summaries of articles highlighting the role "for purinergic signaling in the induction of inflammation and Th17 responses in the pathogenesis of psoriasis" and how "NET formation in response to fungi is mediated by CR3 recognition of -glucan in the context of the ECM."
[ Text ] [ Audio ] - April 1 2013 issue
Summaries of articles highlighting how "specific compartmentalization of signaling molecules upon TCR stimulation can regulate the different activation thresholds of naive and memory CD8+ T cells" and how "DCs control the SHP-1 levels and Ag reactivity of iNKT cell."
[ Text ] [ Audio ] - March 15 2013 issue
Summaries of articles highlighting the role of "MPYS in the recruitment of Ly6Chi monocytes for bacterial clearance during Listeria infections" and how "autoimmunity can result from relaxing the negative regulation of BCR signaling."
[ Text ] [ Audio ] - March 1 2013 issue
Summaries of articles highlighting the "importance of all-trans retinoic acid signaling for proper differentiation of CD8+ T cells into effector and effector memory populations" and how "IL-35 expression on tumor cells increases their resistance to tumor-specific CD8+ T cells."
[ Text ] [ Audio ] - February 15 2013 issue
Summaries of articles highlighting how "TLR9 functions in establishing and breaking B cell tolerance in a model of SLE" and "the role of microRNA-223 in regulating the growth and differentiation of eosinophil progenitor cells."
[ Text ] [ Audio ] - February 1 2013 issue
Summaries of articles highlighting "a mechanistic link between autophagy and lung inflammation in cystic fibrosis" and "the importance of focal adhesion kinase in B cell homeostasis and development."
[ Text ] [ Audio ] - January 15 2013 issue
Summaries of articles highlighting how "differences in trafficking between APCs may account for different TLR9-dependent responses between cell types" and how "siRNA mediated RNA interference is a broadly effective antiviral mechanism."
[ Text ] [ Audio ] - January 1 2013 issue
Summaries of articles highlighting a "new role for Mac-1 as a surface receptor of extracellular dsRNA during viral infection" and a "vital role for TIM-3 in promoting tolerance at the maternal-fetal interface."
[ Text ] [ Audio ] - December 15 2012 issue
Summaries of articles that demonstrate how "miRNA-451 responds uniquely to influenza infection in primary DCs" and examine the role "of CDK2 in promoting the differentiation and suppression of T regulatory cell activity."
[ Text ] [ Audio ] - December 1 2012 issue
Summaries of articles that examine "a mechanism of action cetuximab in EGFR-expressing cancers" and "how the C5a receptor contributes to periodontitis pathogenesis."
[ Text ] [ Audio ] - November 15 2012 issue
Summaries of articles that examine "a role for IL-7 in protection against sepsis" and "explore how intratumoral γδ T cells can serve as prognostic markers in breast cancer."
[ Text ] [ Audio ] - November 1 2012 issue
Summaries of articles that examine "how SerpinB1 influences neutrophil extracellular trap activity" and explore "why autoreactive, anergic B cells are found in the periphery."
[ Text ] [ Audio ] - October 15 2012 issue
Summaries of articles that examine "a role for Adamts12 in protection against inflammation that contributes to asthma" and "how multiple processes during T cell development are influenced by microRNAs."
[ Text ] [ Audio ] - October 1 2012 issue
Summaries of articles that "characterize a unique memory T cell population in the brain" and "describe a role for IRF4 during dendritic cell migration."
[ Text ] [ Audio ] - September 15 2012 issue
Summaries of articles that "discuss how a semaphorin affects West Nile virus pathogenesis" and "use deep-sequencing technology to better understand the generation of antibody diversity."
[ Text ] [ Audio ] - September 1 2012 issue
Summaries of articles that "describe the bone marrow as a site of NK cell proliferation" and "analyze the role of different GTPases during exocytosis."
[ Text ] [ Audio ] - August 15 2012 issue
Summaries of articles that "examine the role of PHD3 in the inflammatory response" and "explore how a microRNA influences multiple sclerosis."
[ Text ] [ Audio ] - August 1 2012 issue
Summaries of articles that "describe an adjuvant that enhances vaccine efficacy in neonates" and "examine a mechanism that silences CD8 gene expression during CD4+ T cell development."
[ Text ] [ Audio ] - July 15 2012 issue
Summaries of articles that "examine maternal T cell responses to fetal antigen" and "characterize how Leishmania donovani disrupts innate immune responses."
[ Text ] [ Audio ] - July 1 2012 issue
Summaries of articles that "characterize immune system defects in patients with Ataxia telangiectasia" and how "glutocortocoid treatment influences alveolar macrophage responses."
[ Text ] [ Audio ] - June 15 2012 issue
Summaries of articles that "explore how BLyS boosts HIV vaccine responses" and "characterize the phenotype and migration of skin B cells."
[ Text ] [ Audio ] - June 1 2012 issue
Summaries of articles that "define CD26 as a marker of human Th17 cells" and "describe how spinal cord injuries impact B cell responses."
[ Text ] [ Audio ] - May 15 2012 issue
Summaries of articles that discuss "how complement activation affects IL-27 production" and "how hypoxia may lead to protection against chronic kidney disease."
[ Text ] [ Audio ] - May 1 2012 issue
Summaries of articles that discuss "the anti-inflammatory properties of resolvin E2" and "how purinergic receptors are involved in HIV-1 infection of macrophages."
[ Text ] [ Audio ] - April 15 2012 issue
Summaries of articles that describe "how memory-like T cells develop" and "how antigen size influences B cell responses."
[ Text ] [ Audio ] - April 1 2012 issue
Summaries of articles that describe "mathematical modeling of NK cell expansion" and "development of the immune system in the tsetse fly."
[ Text ] [ Audio ] - March 15 2012 issue
Summaries of articles that examine "virtual memory T cells" and "how targeting TNF to the vascular endothelium can enhance antitumor responses."
[ Text ] [ Audio ] - March 1 2012 issue
Summaries of articles that examine "the immune response to seminal fluid" and "how Notch signaling influence gastrointestinal immunity."
[ Text ] [ Audio ] - February 15 2012 issue
Summaries of articles that examine "the role of IL-21 during respiratory viral infection" and "how food preservatives influence T helper cell responses."
[ Text ] [ Audio ] - February 1 2012 issue
Summaries of articles that describe "how self-reactive antibodies can contribute to brain tissue damage after stroke" and characterize "a lymphoid cell type involved in allergic airway responses."
[ Text ] [ Audio ] - January 15 2012 issue
Summaries of articles that explore "the role of B cell-derived IL-10 in lupus" and "the effect of helminth infection on T cell polarization."
[ Text ] [ Audio ] - January 1 2012 issue
Summaries of articles that look at "IL-17 and diabetes" and "the source of anti-polysaccharide antibodies in the bone marrow."
[ Text ] [ Audio ] - December 15 2011 issue
Summaries of articles that examine "differences between mouse and rat NK cell receptors" and "how an antibody against dengue virus can affect clot formation."
[ Text ] [ Audio ] - December 1 2011 issue
Summaries of articles that examine "the effect of high affinity T cell receptors on autoimmune disease" and "how dendritic cells take up antigen."
[ Text ] [ Audio ] - November 15 2011 issue
Summaries of articles that explore "the effects heme oxygenase-1 on inflammation" and "regulatory T cell plasticity."
[ Text ] [ Audio ] - November 1 2011 issue
Summaries of articles that describe "the effect of prenatal smoke exposure on lung development" and "how endogenous tumor antigens influence the effectiveness of tumor vaccines."
[ Text ] [ Audio ] - October 15 2011 issue
Summaries of articles that describe "how nematode infection can compromise vaccine efficacy" and "a unique subset of T cells that can counteract multiple myeloma."
[ Text ] [ Audio ] - October 1 2011 issue
Summaries of articles that describe "a link between gum diseases and arthritis" and "an immunological mechanism behind dry eye."
[ Text ] [ Audio ] - September 15 2011 issue
Summaries of articles that describe "the role of caveolin-1 during T cell activation" and "a unique mouse model for the study of IL-10."
[ Text ] [ Audio ] - September 1 2011 issue
Summaries of articles that focus on "how macrophages affect fetal lung development" and "factors that influence peptide immunodominance."
[ Text ] [ Audio ] - August 15 2011 issue
Summaries of articles that focus on "the antibacterial activity of a surfactant protein" and how "resolvins influence colitis."
[ Text ] [ Audio ] - August 1 2011 issue
Summaries of articles that focus on "defining how PD-L1 prevents autoimmunity and transplant rejection" and the "development of knockout mice for the study of immune responses against dimorphic fungi."
[ Text ] [ Audio ] - July 15 2011 issue
Summaries of articles that focus on "how gammaherpesviruses evade the immune system" and "how neutrophils are mobilized during sepsis."
[ Text ] [ Audio ] - July 1 2011 issue
Summaries of articles that focus on "how sleep affects vaccination responses" and the "involvement of the gene CD101 in different autoimmune diseases."
[ Text ] [ Audio ] - June 15 2011 issue
Summaries of articles that focus on "TSLP's role in skin fibrosis" and "contributions of the free radical environment to the differentiation of T helper cells."
[ Text ] [ Audio ] - June 1 2011 issue
Summaries of articles that focus on "the role of TLRs in dorsal root ganglion pain response" and "further X chromosome mosaicism."
[ Text ] [ Audio ] - May 15 2011 issue
Summaries of articles that focus on "the structural basis for the specificity of the T cell receptor" and "the complexities involved in developing a malaria vaccine."
[ Text ] [ Audio ] - May 1 2011 issue
Summaries of articles that focus on "the modulation of IFN-alpha production by NK cells" and "further insight into how the thymic stroma develops."
[ Text ] [ Audio ] - April 15 2011 issue
Summaries of articles that focus on "the relationship of CD1d and cardiolipin" and "the the role of NFIL3 in mucosal immunity."
[ Text ] [ Audio ] - April 1 2011 issue
Summaries of articles that focus on "IL-32 as an anti-viral" and "the importance of chaperones in immunity."
[ Text ] [ Audio ] - March 15 2011 issue
Summaries of articles that focus on "how CCR7 influences adaptive immunity" and "and how OX40 can orchestrate T cell activation."
[ Text ] [ Audio ] - March 1 2011 issue
Summaries of articles that focus on "the role of IgA in tuberculosis" and "the involvement of TIM-3 in cystic fibrosis."
[ Text ] [ Audio ] - February 15 2011 issue
Summaries of articles that focus on "the role of adenosine in sepsis" and "the importance of selenium to immune function."
[ Text ] [ Audio ] - February 1 2011 issue
Summaries of articles that focus on "the organogenesis of secondary lymphoid tissues" and "the roles of dendritic cells."
[ Text ] [ Audio ] - January 15 2011 issue
Summaries of articles that focus on "the role of aging in myeloid function" and "how IgE enhances anti-parasite lymphocyte responses."
[ Text ] [ Audio ] - January 1 2011 issue
Summaries of articles that focus on "the role of APCs in GVHD" and "the involvement of TRAF3 in T cell function."
[ Text ] [ Audio ] - December 15 2010 issue
Summaries of articles that focus on "development of T cell memory in the liver" and "how basophils support plasma cell development."
[ Text ] [ Audio ] - December 1 2010 issue
Summaries of articles that focus on "transcription events in B cell development" and "the role of CD44v6 in neutrophil migration."
[ Text ] [ Audio ] - November 15 2010 issue
Summaries of articles that examine "he role of Mer in tolerance" and "sialylation in tumor immune evasion."
[ Text ] [ Audio ] - November 1 2010 issue
Summaries of articles that focus on "the signaling events that lead to T cell memory" and "the role of arginine in MDSCs."
[ Text ] [ Audio ] - October 15 2010 issue
Summaries of articles that focus on "how amino acid composition of antigenic peptides influences naïve T cells" and "the role of C1q in SLE."
[ Text ] [ Audio ] - October 1 2010 issue
Summaries of articles that focus on "the role of ThPOK" and "how CO2 levels can effect innate immunity."
[ Text ] [ Audio ] - September 15 2010 issue
Summaries of articles that focus on "glutathione in DC redox" and "SHP-1 in effector T cells."
[ Text ] [ Audio ] - September 1 2010 issue
Summaries of articles that look at the role of "nanoparticles in a possible vaccine" and "ICAMs in NK cell adhesion."
[ Text ] [ Audio ] - August 15 2010 issue
Summaries of articles that focus on "Killer Tc17 cells" and "the MHC of the grass carp."
[ Text ] [ Audio ] - August 1 2010 issue
Summaries of articles that focus on "signaling through LIGHT" and "the resurrection of T cell memory."
[ Text ] [ Audio ] - July 15 2010 issue
Summaries of articles that focus on "flagellin in gut defenses" and "IL-33 in atherosclerosis."
[ Text ] [ Audio ] - July 1 2010 issue
Summaries of articles that explore "the role of c-kit in lineage commitment" and "the interactions with mast cells with NK cells and astrocytes."
[ Text ] [ Audio ] - June 15 2010 issue
Summaries of articles that explore "mast celss and their regulation of the blood brain barrier" and "chromatin remodeling in VDJ recombination."
[ Text ] [ Audio ] - June 1 2010 issue
Summaries of articles that explore "the role of IRAK-M in immunosuppression" and "the effect of cigarette smoking on alveolar macrophage migration."
[ Text ] [ Audio ] - May 15 2010 issue
Summaries of articles that explore "epxression and location of the CD8 molecule" and "IFN-gamma expression of NKT cells."
[ Text ] [ Audio ] - May 1 2010 issue
Summaries of articles that explore "the secrets of TLR10" and "mucosal APCs."
[ Text ] [ Audio ] - April 15 2010 issue
Summaries of articles that focus on "the role of COPD on NK cells" and "how CXCL14 promotes the development of arthritis."
[ Text ] [ Audio ] - April 1 2010 issue
Summaries of articles that explore "the role of melatonin in apoptosis" and "the site of IgA class switch recombination."
[ Text ] [ Audio ] - March 15 2010 issue
Summaries of articles that focus on "the epigenetic modification of cytokine genes in T cells" and "the effect of Neisseria infection on HIV replication and transmission."
[ Text ] [ Audio ] - March 1 2010 issue
Summaries of articles that focus on "the role of Sigirr in IEC differentiation" and "the response of Helicobacter pylori to nitric oxide."
[ Text ] [ Audio ] - February 15 2010 issue
Summaries of articles that focus on "the role of IL-23 in Listeria infection" and "the function of CD155 in T cell development."
[ Text ] [ Audio ] - February 1 2010 issue
Summaries of articles that focus on "KIR gene in gibbons" and "intratumoral dendritic cells."
[ Text ] [ Audio ] - January 15 2010 issue
Summaries of articles that focus on "characterization of macrophage migration" and "Vitamin D effects on NF-κB signaling."
[ Text ] [ Audio ] - January 1 2010 issue
Summaries of articles that focus on "PD-1 and T cell exhaustion" and "Calcium flux and the immune synapse."
[ Text ] [ Audio ] - December 15 2009 issue
Summaries of articles that range from "dendritic cell cross-priming" to "Sluggish signaling."
[ Text ] [ Audio ] - December 1 2009 issue
Summaries of articles that focus on "the ectonucleotidase CD39" and "T cell interaction with sialomucins."
[ Text ] [ Audio ] - November 15 2009 issue
Summaries of articles that range from "the role of innate immunity in psoriasis" to "MHC in the turkey."
[ Text ] [ Audio ]; - November 1 2009 issue
Summaries of articles that focus on "the role of RANKL in the intestine" and "macrophage responses to anthrax."
[ Text ] [ Audio ] - October 15 2009 issue
Summaries of articles that focus on "the protective cell wall of Mycobacterium tuberculosis" and "the role of IL-33 in asthma."
[ Text ] [ Audio ] - October 1 2009 issue
Summaries of articles that focus on "chemokines in the lymph node" and "the finer points of MHCI presentation."
[ Text ] [ Audio ] - September 15 2009 issue
Summaries of articles that focus on "CD8+ Treg" and "a novel component of the TLR4 signaling complex."
[ Text ] [ Audio ] - September 1 2009 issue
Summaries of articles that focus on "high affinity B cells" and "mast cell regulation of Treg."
[ Text ] [ Audio ] - August 15 2009 issue
Summaries of articles that focus on "the role of B cells in myocardial infarction" to "the effect of malnutrition on DC development."
[ Text ] [ Audio ] - August 1 2009 issue
Summaries of articles that range from "malaria induced immune exhaustion" to "the role of basophils in RSV."
[ Text ] [ Audio ] - July 15 2009 issue
Summaries of articles that focus on "the role of tristetraprolin in IL-10 signaling" to "diabetes and stem cells."
[ Text ] [ Audio ] - July 1 2009 issue
Summaries of articles that range from "leishmania vaccines" to "repressing colitis."
[ Text ] [ Audio ] - June 15 2009 issue
Summaries of articles that range from "the role of α9 integrin in rheumatoid arthritis" to "gene therapy that targets IgE."
[ Text ] [ Audio ] - June 1 2009 issue
Summaries of articles that range from "leukocyte integrin-mediated crawling on endothelium" to "the RNA binding protein HuR controlling thymocyte development."
[ Text ] [ Audio ] - May 15 2009 issue
Summaries of articles that range from "GRAIL expression on T cells" to "the role of IgE in HIV infection."
[ Text ] [ Audio ] - May 1 2009 issue
Summaries of articles that range from "IL-13 R on T cells" to "breast cancer vaccines."
[ Text ] [ Audio ] - April 15 2009 issue
Summaries of articles that range from "microRNAs in asthma" to "autophagy and bacterial infection."
[ Text ] [ Audio ] - April 1 2009 issue
Summaries of articles that range from "chemokines in lupus" to "the importance of Vitamin D."
[ Text ] [ Audio ] - March 15 2009 issue
Summaries of articles that range from "parasite evasion mechanisms" to "the finer points of TLR4 signaling."
[ Text ] [ Audio ] - March 1 2009 issue
Summaries of articles that focus on "the role of galectin in diabetes" and "immunosuppression from IL-21."
[ Text ] [ Audio ] - February 15 2009 issue
Summaries of articles that focus on topics such as "bystander activation" and "the effect of carbon monoxide on dendritic cells."
[ Text ] [ Audio ] - February 1 2009 issue
Summaries of articles that range from "the role of the adaptor protein known as Act1 or CIKS" and "chicken Immunoglobulin receptors."
[ Text ] [ Audio ] - January 15 2009 issue
Summaries of articles that focus on "mast cell crosstalk" and "a novel IL-4 splice variant."
[ Text ] [ Audio ] - January 1 2009 issue
Summaries of articles that range from "how to define a cortical thymic epithelial cell" to "how to make a simple adjuvant."
[ Text ] [ Audio ] - December 15 2008 issue
Summaries of articles that range from "the complementarity determining region of IgH" to "the role of complement in neurodegeneration."
[ Text ] [ Audio ] - December 1 2008 issue
Summaries of articles focusing on "how the alternative pathway of complement prevents against intestinal injury" to "how retinal pigment epithelia participates in the production of Treg."
[ Text ] [ Audio ] - November 15 2008 issue
Summaries of articles that focus on "the importance of Vitamin D" and "aging innate immune responses."
[ Text ] [ Audio ] - November 1 2008 issue
Summaries of articles that focus on "stem cell quiescence" and "the redefining of the CDR."
[ Text ] [ Audio ] - October 15 2008 issue
Summaries of articles that range from "the integrity of intestinal epithelia" to "the flexibility of B cell memory."
[ Text ] [ Audio ] - October 1 2008 issue
Summaries of articles that include "the role of Annexin in colitis" and "challenging a Th1 and Th17 paradox."
[ Text ] [ Audio ] - September 15 2008 issue
Summaries of articles that range from "marginal zone highways" to "B cells sharing antigens."
[ Text ] [ Audio ] - September 1 2008 issue
Summaries of articles that focus on such diverse topics as "the fugu fish" to "the Friend virus."
[ Text ] [ Audio ] - August 15 2008 issue
Summaries of articles that examine "eosinophil attack," "electric lymphocyte migration," and "the identification of a new type of regulatory T cell."
[ Text ] [ Audio ] - August 1 2008 issue
Summaries of articles that range from "Th17 effectors" to "how IL 10 controls Borrelia infection."
[ Text ] [ Audio ] - July 15 2008 issue
Summaries of articles that range from "maintaining intestinal homeostasis" to "how CpG can do it all."
[ Text ] [ Audio ] - July 1 2008 issue
Summaries of articles that touch on topics as diverse as "why to keep those tonsils in" to "the mysteries of immune tolerance during pregnancy."
[ Text ] [ Audio ]